Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

作者：Abaan Ogan Demir; Mutlu Pelin Kaya; Baran Yusuf; Atalay Can; Gunduz Ufuk^*

来源：Cancer Investigation, 2009, 27(2): 201-205.

DOI：10.1080/07357900802173562

• Multidrug resistance
• MDR
• MRP1
• Breast cancer
• Chemotherapy
• MRP Family

Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.

• 出版日期2009