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摘要
A simple and efficient palladium-catalyzed oxidative coupling between 2-alkynyl anilines and allylic alcohols is described by using cheap and green dioxygen as the oxidant. These cross-couplings have a large functional group tolerance and are of higher reactivity toward electron nonbaised allylic alcohols. The resultant beta-indole ketones are readily converted to pharmaceutically significant beta-indole alcohol/amine and pyrrolo[2,1-a]isoquinolines.
- 出版日期2013-12-6
- 单位华南理工大学
