Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease

作者：Morgan A R^*; Hamilton G; Turic D; Jehu L; Harold D; Abraham R; Hollingworth P; Moskvina V; Brayne C; Rubinsztein D C; Lynch A; Lawlor B; Gill M; O'Donovan M; Powell J; Lovestone S; Williams J; Owen M J

来源：American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 2008, 147B(6): 727-731.

DOI：10.1002/ajmg.b.30670

• late-onset Alzheimer's disease
• chromosome 10
• SNP
• association

Late-onset Alzheimer's disease (LOAD) is a genetically complex neurodegenerative disorder. Currently, only the epsilon 4 allele of the Apolipoprotein E gene has been identified unequivocally as a genetic susceptibility factor for LOAD. Others remain to be found. In 2002 we observed genome-wide significant evidence of linkage to a region on chromosome 10q11.23-q21.3 [Myers et al. (2002) Am J Med Genet 114:235-244]. Our objective in this study was to test every gene within the maximum LOD-1 linkage region, for association with LOAD. We obtained results for 528 SNPs from 67 genes, with an average density of I SNP every 10 kb within the genes. We demonstrated nominally significant association with LOAD for 4SNPs: rs1881747 near DKK1 (P = 0.011, OR = 1.24), rs2279420 in ANK3 (P = 0.022, OR = 0.79), rs2306402 in CTNNA3 (P = 0.024, OR = 1.18), and rs5030882 in CXXC6 (P=0.046, OR=1.29) in 1,160 cases and 1,389 controls. These results would not survive correction for multiple testing but warrant attempts at confirmation in independent samples.

• 出版日期2008-9-5
• 单位河北医科大学