3q27 Aberrations in a Childhood Ovary Teratoma With Associated Malignant Germ Cell Component

作者：Brassesco Maria Sol^*; Castro Gamero Angel Mauricio; Valera Elvis Terci; Neder Luciano; Elias Jorge Jr; Tone Luiz Gonzaga

来源：Pediatric Blood and Cancer, 2009, 52(3): 398-401.

DOI：10.1002/pbc.21877

• cancer
• children
• cytogenetics
• teratoma
• 3q27

Cytogenetic Studies of childhood ovary tumors have been poorly described. in the present article, the cytogenetic findings of an ovarian teratoma with malignant germ cell (yolk-sac) component occurring in an 8-year-old female are detailed. GTG-banding showed a karyotype of 46,XX, t(3;20)(q27;q13.3) [4]/46,XX, del3q27 [3]/46,XX [30]. Previous Studies have demonstrated common sites of loss of heterozygosity at 3q27-q28 region in different types of cancer, suggesting the presence of tumor Suppressor genes within this region. Pediatr Blood Cancer 2009;52:398-401.

• 出版日期2009-3