Absence of an Important Vaccine and Diagnostic Target in Carriage- and Disease-Related Nontypeable Haemophilus influenzae

作者:Smith Vaughan Heidi C*; Chang Anne B; Sarovich Derek S; Marsh Robyn L; Grimwood Keith; Leach Amanda J; Morris Peter S; Price Erin P
来源:Clinical and Vaccine Immunology, 2014, 21(2): 250-252.
DOI:10.1128/CVI.00632-13

摘要

Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.

  • 出版日期2014-2