Asymmetric synthesis of beta'-amino-alpha-beta-enones via addition of alpha,beta-unsaturated ketone-derived enolates to chiral N-phosphonyl imines

作者：Xiong Yiwen; Mei Haibo; Han Jianlin^*; Li Guigen; Pan Yi

来源：Tetrahedron Letters, 2014, 55(15): 2476-2479.

DOI：10.1016/j.tetlet.2014.03.005

• N-Phosphonyl imine
• alpha,beta-Unsaturated ketone
• Asymmetric Mannich reaction
• beta'-Amino-alpha,beta-enones
• Diastereoselectivity

Efficient asymmetric Mannich addition reactions between alpha,beta-unsaturated ketone derived enolates and N-phosphonyl imines were reported. These reactions could proceed smoothly for a variety of imine substrates with good (up to 96%) chemical yields and excellent diastereoselectivities (up to 98:2 dr). The method reported in this work provides an easy access to chiral beta'-amino-alpha,beta-enones.

• 出版日期2014-4-9
• 单位南京大学