科研之友
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摘要
The use of 1,4-dithiothreitol (DTT) as an acetal or ketal exchange reagent and camphorsulfonic acid (CSA) as a catalyst permitted the efficient removal of benzylidene acetal and isopropylidene ketal protecting groups under mild conditions. A variety of acetal and ketal protected carbohydrates were deprotected with this method in 78-98% yields. In addition, terminal isopropylidene ketal or benzylidene acetal was selectively cleaved in the presence of internal isopropylidene ketal. Moreover, it was found that an unusual seven-membered 1,3-dithiepane was formed during the deprotection of benzylidene acetal with DTT.
- 出版日期2018-8-21
- 单位华中科技大学
