Short- and Long-Intracortical Inhibition in Incomplete Spinal Cord Injury

作者：Mi Yiqun P; Bailey Aaron Z; Nelson Aimee J^*

来源：Canadian Journal of Neurological Sciences, 2016, 43(1): 183-191.

DOI：10.1017/cjn.2015.310

• contraction
• flexor carpi radialis
• LICI
• muscle
• SCI
• SICI
• TMS

Background: Short- (SICI) and long-interval intracortical inhibition (LICI) are involved in the control of movement and movement initiation. Alterations to the two circuits can result in direct alterations to the physiology of the muscles and can be used to explain the physiological changes to individuals with spinal cord injury (SCI). Objective: To probe changes in GABAergic function by characterizing the recruitment curves of SICI and LICI interval intracortical inhibition in an upper limb muscle in chronic SCI participants with injury between C3 and C7. Methods: Recruitment curves were elicited with conditioning stimulus intensities determined as a percentage of active motor threshold (AMT) (SICI, 60% to 110% AMT; LICI, 90% to 130% AMT) and recorded from the flexor carpi radialis muscle during an isometric contraction equal to 15% to 20% of maximum voluntary contraction. Results: AMT was greater and motor-evoked potential sizes were lower in SCI compared with uninjured controls. SICI magnitude was not different between groups, although the range of conditioning stimulus intensities to evoke SICI was unique to each group. LICI was reduced in the control group during active contraction and remained present in SCI. Discussion: LICI was increased in the actively contracted flexor carpi radialis muscle in individuals with SCI compared with age-matched controls. These findings indicate that GABA(B) function mediating LICI is different in SCI versus controls. Conclusions: Increased LICI in SCI may be attributed to the medication baclofen or to changes in the neural mechanisms controlling contraction-related modulation of the LICI circuit.

• 出版日期2016-1