Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to decapping scavenger activity monitoring

作者：Kasprzyk Renata; Kowalska Joanna^*; Wieczorek Zbigniew; Szabelski Mariusz; Stolarski Ryszard; Jemielity Jacek^*

来源：Organic and Biomolecular Chemistry, 2016, 14(16): 3863-3868.

DOI：10.1039/c6ob00419a

7-Methylguanosine (m(7)G) nucleotides labelled with acetylpyrene (AcPy) were synthesized as fluorescent mRNA 5' end (cap) analogues. The unique fluorescent properties of m(7)G-AcPy conjugates, different from G-AcPy, can be applied to studying various mRNA cap-related processes including the evaluation of putative inhibitors of DcpS enzyme-a therapeutic target in neuromuscular diseases.

• 出版日期2016