Allo-hematopoietic stem cell transplantation is a potential treatment for a patient with a combined disorder of hereditary spherocytosis

作者：Zhang Xiao-hui; Fu Hai-xia; Xu Lan-ping; Liu Dai-hong; Chen Huan; Han Wei; Chen Yu-hong; Wang Feng-rong; Wang Jing-zhi; Wang Yu; Zhao Ting; Liu Kai-yan; Huang Xiao-jun^*

来源：Chinese Medical Journal, 2012, 125(5): 947-950.

DOI：10.3760/cma.j.issn.0366-6999.2012.05.039

• hereditary spherocytosis
• allogeneic stem cell transplantation
• chronic myelogenous leukemia

Both human hereditary spherocytosis (HS) and chronic myelogenous leukemia (CML) are life threatening. Herein we have reported the case of a woman with a combined disorder of HS and CML who underwent the matched sibling allogeneic stem cell transplantation. The complete donor erythroid cells were obtained. The red blood cell counts significantly improved throughout life comparing with pre-hematopoietic stem cell transplantation (HSCT). Reticulocyte counts normalized, and BCR-ABL was cleared away. The total bilirubin level was also corrected in this recipient. Our case is a rare example with a combined disorder of HS and CML following allogeneic stem cell transplantation. HS was not a contraindication for patient in the matched sibling transplant setting. Chin Med J 2012;125(5):947-950

• 出版日期2012-3-5
• 单位北京大学