Neoadjuvant Chemotherapy Combining Docetaxel, Cisplatin and S-1 in Gastric Cancer with Para-aortic Lymph Node Metastases: Report of Five Cases

作者：Fushida Sachio^*; Fujimura Takashi; Oyama Katsunobu; Kinoshita Jun; Fujita Hideto; Ninomiya Itasu; Ohta Tetsuo

来源：Hepato-Gastroenterology, 2010, 57(104): 1650-1654.

• Gastric cancer
• Neoadjuvant chemotherapy
• Para-aortic lymph node metastases
• Docetaxel
• Cisplatin
• S-1

We report on five patients with a median age of 56 years (range, 53-68 years) who were diagnosed as advanced gastric cancer with para-aortic lymph node metastases, determined by gastrofiberscope and abdominal spiral computed tomography. These patients received intravenous docetaxel (30mg/m(2)) and cisplatin (30mg/m(2)) on day 1, 15 and oral S-1 (40mg/m(2) bid) on days 1-14 every 4 weeks. After two cycles of neoadjuvant chemotherapy, all patients received total gastrectomy with D2 lymphadenectomy plus para-aortic lymph nodes dissection. No patient revealed hematological or non-hematological toxicities associated with the chemotherapy (more than grade 2). The postoperative courses were uneventful without major surgery-related complications. Pathological complete response was confirmed one patient in primary lesion and three patients in metastatic lymph nodes including para-aortic lymph nodes. All of five patients are alive without recurrence (median: 36 months, 21-46 months). Thus, neoadjuvant chemotherapy described here may be rather promising regimen for advanced gastric cancer with para-aortic lymph node metastases, considering its low grade toxicities and pathological responses.

• 出版日期2010-12