Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16

作者：Pebody Richard G^*; Sinnathamby Mary A; Warburton Fiona; Andrews Nick; Boddington Nicola L; Zhao Hongxin; Yonova Ivelina; Ellis Joanna; Tessier Elise; Donati Matthew; Elliot Alex J; Hughes Helen E; Pathirannehelage Sameera; Byford Rachel; Smith Gillian E; de Lusignan Simon; Zambon Maria

来源：Eurosurveillance, 2018, 23(25): 35-49.

DOI：10.2807/1560.7917.ES.2o18.23.25.1700496

The 2015/16 influenza season was the third season of the introduction of an intra-nasally administered live attenuated influenza vaccine (LAIV) for children in England. All children aged 2-6 years were offered LAIV, and in addition, a series of geographically discrete areas piloted vaccinating school-age children 7-11 years old. Influenza A(H1N1)pdmo9 was the dominant circulating strain during 2015/16 followed by influenza B. We measured influenza vaccine uptake and the overall and indirect effect of vaccinating children of primary school -age, by comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot and non-pilot areas in England. Uptake of 57.9% (range: 43.6-72.0) was achieved in the five pilot areas for children aged 5-11 years. In pilot areas, cumulative emergency department respiratory attendances, influenza-confirmed hospitalisations and intensive care unit admissions were consistently lower, albeit mostly non-significantly, in targeted and non-targeted age groups compared with non-pilot areas. Effect sizes were less for adults and more severe endpoints. Vaccination of healthy primary school-age children with LAIV at moderately high levels continues to be associated with population-level reductions in influenza-related respiratory illness. Further work to evaluate the population-level impact of the programme is required.

• 出版日期2018-6-21