Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection

作者：Cnops J; Kauffmann F; De Trez C; Baltz T; Keirsse J; Radwanska M; Muraille E; Magez S^*

来源：Parasite Immunology, 2016, 38(10): 642-647.

DOI：10.1111/pim.12344

• B lymphocyte
• inflammation
• Trypanosoma spp
• trypanosomiasis

African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T.b.gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN- and TNF- during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.

• 出版日期2016-10