Admission Lipoprotein-Associated Phospholipase A(2) Activity Is Not Associated with Long-Term Clinical Outcomes after ST-Segment Elevation Myocardial Infarction

作者：Woudstra Pier; Damman Peter; Kuijt Wichert J; Kikkert Wouter J; Grundeken Maik J; van Brussel Peter M; Stroobants An K; van Straalen Jan P; Fischer Johan C; Koch Karel T; Henriques Jose P S; Piek Jan J; Tijssen Jan G P; de Winter Robbert J^*

来源：PLos One, 2014, 9(5): e96251.

DOI：10.1371/journal.pone.0096251

Background: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity is a biomarker predicting cardiovascular diseases in a real-world. However, the prognostic value in patients undergoing primary percutaneous coronary intervention (pPCI) for ST-segment elevation myocardial infarction (STEMI) on long-term clinical outcomes is unknown.
Methods: Lp-PLA(2) activity was measured in samples obtained prior to pPCI from consecutive STEMI patients in a high-volume intervention center from 2005 until 2007. Five years all-cause mortality was estimated with the Kaplan-Meier method and compared among tertiles of Lp-PLA(2) activity during complete follow-up and with a landmark at 30 days. In a subpopulation clinical endpoints were assessed at three years. The prognostic value of Lp-PLA(2), in addition to the Thrombolysis In Myocardial Infarction or multimarker risk score, was assessed in multivariable Cox regression.
Results: The cohort (n = 987) was divided into tertiles (low <144, intermediate 144-179, and high >179 nmol/min/mL). Among the tertiles differences in baseline characteristics associated with long-term mortality were observed. However, no significant differences in five years mortality in association with Lp-PLA(2) activity levels were found; intermediate versus low Lp-PLA(2) (HR 0.97; CI 95% 0.68-1.40; p = 0.88) or high versus low Lp-PLA(2) (HR 0.75; CI 95% 0.51-1.11; p = 0.15). Both in a landmark analysis and after adjustments for the established risk scores and selection of cases with biomarkers obtained, non-significant differences among the tertiles were observed. In the subpopulation no significant differences in clinical endpoints were observed among the tertiles.
Conclusion: Lp-PLA(2) activity levels at admission prior to pPCI in STEMI patients are not associated with the incidence of short and/or long-term clinical endpoints. Lp-PLA(2) as an independent and clinically useful biomarker in the risk stratification of STEMI patients still remains to be proven.

• 出版日期2014-5-1