Association between depression and malnutrition-inflammation complex syndrome in patients with continuous ambulatory peritoneal dialysis

作者：Li, Zhi-Jian; An, Xin; Mao, Hai-Ping; Wei, Xin; Chen, Jie-Hui; Yang, Xiao; Zhou, Shu-Feng; Li, Zhi-Bin; Yu, Xue-Qing^*

来源：International Urology and Nephrology, 2011, 43(3): 875-882.

DOI：10.1007/s11255-011-9917-x

• Continuous ambulatory peritoneal dialysis (CAPD)
• Depression
• Hamilton Depression Scale (HAMD)
• Malnutrition-inflammation score (MIS)
• Malnutrition-inflammation complex syndrome (MICS)

Depression, the most common psychological disorder among patients with end-stage renal disease (ESRD), is associated with poor survival. The prevalence of depression and its relation with the malnutrition-inflammation complex syndrome (MICS) have not yet been clearly defined in Chinese continuous ambulatory peritoneal dialysis (CAPD) patients. @@@ A total of 142 patients on CAPD were enrolled in the First Affiliated Hospital of Sun Yat-Sen University. The Hamilton Depression Scale (HAMD) and the malnutrition-inflammation score (MIS) were used for depression and MICS evaluation, respectively. Clinical, socioeconomic, and malnutrition-inflammation factors were compared among patients with and without depression. Binary regression analysis was performed to investigate the independent association between depression and MICS. @@@ The mean HAMD and MIS scores were 7.12 +/- A 5.28 and 4.45 +/- A 3.56, respectively. According to HAMD, 37 patients (26.1%) had depression and 70 patients (49.3%) had potential depression. Older age, longer dialysis vintage, worse residual renal function, lower employment and reimbursement status, and higher comorbidity index were positively correlated with depression. Compared to non-depressed patients, the depressed ones also showed lower levels of serum albumin and higher levels of C-reactive protein (CRP). Correlation results showed that the HAMD scores were significantly and positively correlated with MIS (r = 0.46, P < 0.01). Moreover, the incidence of peritonitis was significantly higher in depressed compared to non-depressed patients. Binary regression analysis showed that MIS was the only independent risk factor for depression. @@@ Depression is commonly encountered in Chinese CAPD patients. A close relationship exists between depression and MICS.

• 出版日期2011-9
• 单位中山大学