Anatomical study of serotonergic innervation and 5-HT1A receptor in the human spinal cord

作者：Perrin F E; Gerber Y N; Teigell M; Lonjon N; Boniface G; Bauchet L; Rodriguez J J; Hugnot J P; Privat A M^*

来源：Cell Death & Disease, 2011, 2: e218.

DOI：10.1038/cddis.2011.98

• genito-urinary tract
• locomotion
• nociceptive pathway
• serotonin

Serotonergic innervation of the spinal cord in mammals has multiple roles in the control of motor, sensory and visceral functions. In rats, functional consequences of spinal cord injury at thoracic level can be improved by a substitutive transplantation of serotonin (5-HT) neurons or regeneration under the trophic influence of grafted stem cells. Translation to either pharmacological and/or cellular therapies in humans requires the mapping of the spinal cord 5-HT innervation and its receptors to determine their involvement in specific functions. Here, we have performed a preliminary mapping of serotonergic processes and serotonin-lA (5-HT1A) receptors in thoracic and lumbar segments of the human spinal cord. As in rodents and non-human primates, 5-HT profiles in human spinal cord are present in the ventral horn, surrounding motoneurons, and also contact their presumptive dendrites at lumbar level. 5-HT1A receptors are present in the same area, but are more densely expressed at lumbar level. 5-HT profiles are also present in the intermediolateral region, where 5-HT1A receptors are absent. Finally, we observed numerous serotonergic profiles in the superficial part (equivalent of Rexed lamina II) of the dorsal horn, which also displayed high levels of 5-HT1A receptors. These findings pave the way for local specific therapies involving cellular and/or pharmacological tools targeting the serotonergic system. Cell Death and Disease (2011) 2, e218; doi: 10.1038/cddis.2011.98; published online 13 October 2011

• 出版日期2011-10