A Case of Fatal Late Vasospasm in a Patient with a Recurrent, Supratentorial Rhabdoid Primitive Neuroectodermal Tumor: Possible Molecular Implications

作者：Miscusi Massimo^*; De Martino Luca; Antonelli Manila; Mangino Giorgio; Ricciardi Luca; Spinelli Gianpaolo; Forcato Stefano; Calogero Antonella; Petrozza Vincenzo; Ragona Giuseppe; Raco Antonino

来源：Turkish Neurosurgery, 2014, 24(5): 793-798.

DOI：10.5137/1019-5149.JTN.9388-13.1

• PNET
• Rhabdoid cells
• Complication
• Cerebral ischemia
• Vasospasm

We report the case of a 44-year-old man who experienced a fatal and untreatable delayed vasospasm after resection of a recurrent temporal IV grade primitive neuroectodermal tumor (PNET). The histological analysis demonstrated a rare rhabdoid variant of the tumor with a diffuse myxoid degeneration; molecular investigations demonstrated an upregulation of IL-beta and IL-6 expression in the recurrence.
We reviewed the pathophysiology of the vasospasm that occurs after tumors resection, and due to the rarity of case, we speculated on the possibility that specific histological and molecular features of the tumor could have contributed to the delayed and fatal complication.

• 出版日期2014-9