Nickel-Catalyzed Enantioselective Alkylative Coupling of Alkynes and Aldehydes: Synthesis of Chiral Allylic Alcohols with Tetrasubstituted Olefins

作者：Yang Yun; Zhu Shou Fei; Zhou Chang Yue; Zhou Qi Lin^*

来源：Journal of the American Chemical Society, 2008, 130(43): 14052-+.

DOI：10.1021/ja805296k

A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc has been realized by using bulky spirobiindane phosphoramidite ligands, affording allylic alcohols with a tetrasubstituted olefin functionality in high yields, high regioselectivities, and excellent enantioselectivities.

• 出版日期2008-10-29
• 单位南开大学