A High-Fat Diet Increases Oxidative Renal Injury and Protein Glycation in D-Galactose-Induced Aging Rats and Its Prevention by Korea Red Ginseng

作者：Park Sok^*; Kim Chan Sik; Min Jinah; Lee Soo Hwan; Jung Yi Sook

来源：Journal of Nutritional Science and Vitaminology, 2014, 60(3): 159-166.

DOI：10.3177/jnsv.60.159

• age-related renal injury
• D-galactose
• high-fat diet
• Korean red ginseng
• oxidative stress

Declining renal function is commonly observed with age. Obesity induced by a high-fat diet (HFD) may reduce renal function. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury and have an anti-aging effect. This study was designed to investigate whether HFD would accelerate the D-galactose-induced aging process in the rat kidney and to examine the preventive effect of KRG on HFD and D-galactose-induced aging-related renal injury. When rats with D-galactose-induced aging were fed an HFD for 9 wk, enhanced oxidative DNA damage, renal cell apoptosis, protein glycation, and extracellular high mobility group box 1 protein (HMGB1), a signal of tissue damage. were observed in renal glomerular cells and tubular epithelial cells. However, treatment of rats with HFD-plus D-galactose-induced aging with KRG restored all of these renal changes. Our data suggested that a long-term HFD may enhance D-galactose-induced oxidative renal injury in rats and that this age-related renal injury could be suppressed by KRG through the repression of oxidative injury.

• 出版日期2014-6
• 单位南宁师范大学