Differential Sensitivities of Three Strains of Drosophila melanogaster (Diptera: Drosophilidae) to Imipramine as an Antidepressant Drug

作者：Fakoorziba M R; Eghbal M H; Eghbal F^*

来源：Asian Journal of Animal and Veterinary Advances, 2012, 7(9): 898-903.

DOI：10.3923/ajava.2012.898.903

• Toxicity
• imipramine
• antidepressant
• Drosophila melanogaster

In developing world, with progression in modernity and industrialization and synthesis of new chemicals and drugs, man, animal and their ecosystem are constantly threatened by wild range of chemical substances. Several of which are known to be mutagenic, carcinogenic and teratogenic. The antidepressant drugs like imipramine and paroxetine are long-term use administered to many patients and they can cause so many complications and side effects. So, the differential sensitivity of three strains of Drosophila melanogaster for imipramine hydrochloride, an antidepressant drug has been tested by larval feeding. Wheat cream agar medium as normal food medium was used for breeding of Drosophila flies. LC50 of imipramine was estimated by the larval feeding method and sub lethal concentrations of imipramine were selected. The effect of drug on viability, rate of development and sex ratio was analyzed. The results revealed that all three concentrations could reduce viability and significantly delay development. Among the three strains, Oregan-K, the wild type was found to be the most resistant. Sex ratio deviation was significant in concentration of 1 and 2 g L-1 of imipramine in Oregan-K but in two mutant strains the deviation was insignificant.

• 出版日期2012-9