An efficient FeCl3-catalyzed amidation reaction of secondary benzylic and allylic alcohols with carboxamides or p-toluenesulfonamide

作者：Jana Umasish^*; Maiti Sukhendu; Biswas Srijit

来源：Tetrahedron Letters, 2008, 49(5): 858-862.

DOI：10.1016/j.tetlet.2007.11.176

• ferric chloride
• amidation reactions
• alcohols
• atom-economical
• inexpensive

A simple, inexpensive, environmentally friendly and high yielding amidation reaction of benzylic and allylic alcohols with primary amides using a catalytic amount of FeCl3 (5 mol %) is described. Direct substitution of various amides such as benzamide, sulfonamide, acetamide and acrylamide is reported, and this method also works on a large scale in high yield.

• 出版日期2008-1-28