A facile one-pot preparation of meso-hydroxymethylporphyrins via a sequential SNAr reaction with (2-pyridyldimethylsilyl)methyllithium followed by hydrolysis and aerobic oxidation

作者：Takanami Toshikatsu^*; Matsumoto Jun; Kumagai Yoko; Sawaizumi Aoyo; Suda Kohji

来源：Tetrahedron Letters, 2009, 50(1): 68-70.

DOI：10.1016/j.tetlet.2008.10.087

The first, direct meso-hydroxymethylation of 5,15-substituted porphyrins can effectively be obtained by a simple one-pot procedure involving a sequential SNAr reaction of porphyrins with (2-pyridyidimethylsilyl)methyl lithium, followed by hydrolysis and aerobic oxidation at ambient 02 pressure.

• 出版日期2009-1-7