科研之友
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摘要
Pathogenic mutations of the genes encoding isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) occur in people with acute myeloid leukemia or other tumors. A new study identifies a dependence of IDH-mutated cells on the antiapoptosis regulator BCL-2 and indicates a 'synthetic lethal' strategy for the treatment of leukemias.
- 出版日期2015-2
