Ascorbic Acid-Initiated Tandem Radical Cyclization of N-Arylacrylamides to Give 3,3-Disubstituted Oxindoles

作者：Liu, Sheng; Cheng, Pi^*; Liu, Wei; Zeng, Jian-Guo

来源：Molecules, 2015, 20(9): 15631-15642.

DOI：10.3390/molecules200915631

• N-arylacrylamides
• 3
• 3-disubstituted oxindoles
• tandem cyclization
• ascorbic acid
• 4-nitroaniline

An ascorbic acid-promoted and metal-free tandem room temperature cyclization of N-arylacrylamides with 4-nitrobenzenediazonium generated in situ was developed. This reaction proceeds smoothly through a radical mechanism and provides an environmentally friendly alternative approach to biologically active 3-alkyl-3-benzyloxindoles, avoiding the use of excess oxidants and light irradiation.

• 出版日期2015-9
• 单位湖南农业大学