Aerosolized Gentamicin Reduces the Burden of Tuberculosis in a Murine Model

作者：Roy Chad J; Sivasubramani Satheesh K; Dutta Noton K; Mehra Smriti; Golden Nadia A; Killeen Stephanie; Talton James D; Hammoud Badre E; Didier Peter J; Kaushal Deepak^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(2): 883-886.

DOI：10.1128/AAC.05633-11

Tuberculosis (TB) is a major infectious disease problem: 1.7 million people annually die due to TB. Emergence of drug-resistant Mycobacterium tuberculosis and the lack of new antibiotics have exacerbated the situation. There is an urgent need to develop or repurpose drugs against TB. We evaluated inhaled gentamicin as direct respiratory system-targeted therapy in a murine model of TB. Aerosolized-gentamicin-treated mice showed significantly reduced lung M. tuberculosis loads and fewer granulomas relative to untreated controls. These results suggest that direct delivery of antibiotics to the respiratory system may provide therapeutic benefit to conventional treatment regimes for treatment of pulmonary TB.

• 出版日期2012-2