Modification of bipolar lipid conformation at the air/water interface by a single stereochemical variation

作者：Terme Nolwenn; Jacquemet Aicia; Benvegnu Thierry; Vie Veronique; Lemiegre Loic^*

来源：Chemistry and Physics of Lipids, 2014, 183: 9-17.

DOI：10.1016/j.chemphyslip.2014.04.008

• Archaea
• Tetraether lipid
• Air/water interface
• Stereochemistry
• Stretched/bent conformation

This article describes the design and the synthesis of two analogues of archaeal bipolar lipids that differ only by the configuration of a single stereogenic centre on a glyceryl moiety. The corresponding comparative physicochemical study by tensiometry/ellipsometry and atomic force microscopy provided a set of data that points out the effect of this single stereochemical variation. The two epimers revealed different conformations at the air/water interface resulting in a more or less tendency for a bent or a stretched conformation. It strengthens the importance of the stereochemistry in such bipolar lipid packing.

• 出版日期2014-10