Awara (Astrocaryum vulgare M.) pulp oil: Chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation

作者：Bony Emilie; Boudard Frederic; Brat Pierre; Dussossoy Emilie; Portet Karine; Poucheret Patrick; Giaimis Jean; Michel Alain^*

来源：Fitoterapia, 2012, 83(1): 33-43.

DOI：10.1016/j.fitote.2011.09.007

• Anti-inflammatory activities
• Awara (Astrocaryum vulgare M.) pulp oil
• Carotenoids
• Fatty acids
• Phytosterols
• Tocopherols

Awara (Astrocaryum vulgare M.) is a palm fruit mainly used in nutrition. We analysed the pulp oil for fatty acid, tocopherol, carotenoid, and phytosterol and we evaluated whether this oil may attenuate inflammation in vivo. In an endotoxic shock model, awara pulp oil treatment decreased pro-inflammatory cytokines and increased anti-inflammatory cytokines. In a pulmonary inflammation model, awara pulp oil treatment reduced eosinophil and lymphocyte numbers recovered into the broncho-alveolar lavages. These results suggest that awara pulp oil administration can efficiently counteract an acute and chronic inflammatory response in vivo that is probably mediated by fatty acids and minor compounds.

• 出版日期2012-1