Superparamagnetic iron oxide nanoparticles coated with a folate-conjugated polymer

作者：Zhang Quan; Wang Chenhong; Qiao Lei; Yan Husheng^*; Liu Keliang

来源：Journal of Materials Chemistry, 2009, 19(44): 8393-8402.

DOI：10.1039/b910439a

Folate-functionalized magnetic fluids were prepared by direct chemisorption of a folate-tetra(ethylene glycol)-poly(glycerol monoacrylate) (FA-TEG-PGA) conjugate on Fe(3)O(4) nanoparticles. In the magnetic fluids, the PGA block of FA-TEG-PGA was chemisorbed onto the Fe(3)O(4) nanoparticle surface through its 1,2-diol groups, while the TEG chain conjugated with FA extended into the water matrix. Characterization by transmission electron microscopy, X-ray diffraction and a vibrating sample magnetometer indicated that the pure Fe(3)O(4) superparamagnetic nanoparticles were formed and the coating process did not significantly affect the size and structure of Fe(3)O(4) nanoparticles. Fourier transform infrared spectroscopy, UV-vis spectroscopy, thermogravimetric analysis and X-ray photoelectron spectroscopy confirmed the successful coating of FA-TEG-PGA on the Fe(3)O(4) nanoparticles, suggested a coating mechanism for the FA-TEG-PGA, and revealed the maximum weight ratio of FA-TEG-PGA to Fe(3)O(4). The dispersion of FA-TEG-PGA-coated Fe(3)O(4) nanoparticles possessed excellent stability over a wide range of pH and salt concentrations. Such folate-functionalized magnetic fluids are expected to be targeting contrast agents for magnetic resonance imaging (MRI) applications. This approach represents a new strategy to synthesize functionalized magnetic nanoparticles that form stable dispersions in water and facilitates potential biomedical applications of these magnetic nanoparticles.

• 出版日期2009
• 单位南开大学