A newly developed lubricant, chitosan laurate, in the manufacture of acetaminophen tablets

作者：Bani Jaber Ahmad; Kobayashi Asuka; Yamada Kyohei; Haj Ali Dana; Uchimoto Takeaki; Iwao Yasunori^*; Noguchi Shuji; Itai Shigeru

来源：International Journal of Pharmaceutics, 2015, 483(1-2): 49-56.

DOI：10.1016/j.ijpharm.2015.02.014

• Chitosan laurate
• Magnesium stearate
• Lubricant properties
• Tablet characteristics
• Tableting

To study the usefulness of chitosan laurate (CS-LA), a newly developed chitosan salt, as a lubricant, lubrication properties such as the pressure transmission ratio and ejection force were determined at different concentrations of CS-LA in tableting. In addition, tablet properties such as the tensile strength, disintegration time, and dissolution behavior, were also determined. When CS-LA was mixed at concentrations of 0.1%-3.0%, the pressure transmission ratio was increased in a concentration-dependent manner, and the value at a CS-LA concentration of 3% was equal to that of magnesium stearate (Mg-St), a widely used lubricant. Additionally, a reduction in the ejection force was observed at a concentration from 1%, proving that CS-LA has good lubrication performance. A prolonged disintegration time and decreased tensile strength, which are known disadvantages of Mg-St, were not observed with CS-LA. Furthermore, with CS-LA, retardation of dissolution of the drug from the tablets was not observed. Conjugation of CS with LA was found to be quite important for both lubricant and tablet properties. In conclusion, CS-LA should be useful as an alternative lubricant to Mg-St.

• 出版日期2015-4-10