科研之友
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摘要
The synthesis of a new lipophilic thioflavin-T analogue (2-[4'-(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [C-11]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [C-11]6 is a promising amyloid imaging agent for Alzheimer's disease.
- 出版日期2002-2-11
