摘要
We develop a single quantum dot ( QD)-based nanosensor for the signal-on detection of DNA methyltransferase ( MTase). By integration of single-molecule counting with the QD-based fluorescence resonance energy transfer ( FRET), the proposed nanosensor can sensitively detect DNA MTase with a detection limit of as low as 0.002 U mL(-1), and it can be further applied for inhibitor screening and accurate detection of DNA MTase in complex biological samples.
- 出版日期2017-6-28
- 单位山东师范大学