Microfluidics Fabrication of Soft Microtissues and Bottom-Up Assembly

作者：Ma, Shaohua^*; Mukherjee, Nobina

来源：Advanced Biosystems, 2018, 2(9): 1800119.

DOI：10.1002/adbi.201800119

• extracellular matrix
• microfibers
• microfluidics
• microgels
• microtissues

Soft microtissues comprising living cells and supportive matrices have attracted the attention of researchers for their potential as in vitro organ models that represent the patient's tissue heterogeneity, as well as building blocks for artificial organs or regenerative tissues. Microfluidics is known for its capability to produce monodisperse microstructures in high-throughput. This review summarizes the progress on microfluidics fabrication of hydrogel-based microstructures and soft microtissues, and the challenges faced by this field. It mainly focuses on the strengths and limitations of microfluidics fabrication of extracellular matrix (ECM)-based microtissues as in vitro tissue mimics. ECM-based microtissues hold promise to alter the course of regenerative and precision medicine.

• 出版日期2018-9
• 单位清华大学