High temporal resolution dynamic MRI and arterial input function for assessment of GFR in pediatric subjects

作者：Yoruk Umit^*; Saranathan Manojkumar; Loening Andreas M; Hargreaves Brian A; Vasanawala Shreyas S

来源：Magnetic Resonance in Medicine, 2016, 75(3): 1301-1311.

DOI：10.1002/mrm.25731

• glomerular filtration rate estimation
• high spatiotemporal resolution dynamic imaging
• arterial input function estimation
• urography
• dynamic contrast enhancement

PurposeTo introduce a respiratory-gated high-spatiotemporal-resolution dynamic-contrast-enhanced MRI technique and a high-temporal-resolution aortic input HTR-AIF) estimation method for glomerular filtration rate (GFR) assessment in children.
MethodsA high-spatiotemporal-resolution DCE-MRI method with view-shared reconstruction was modified to incorporate respiratory gating, and an AIF estimation method that uses a fraction of the k-space data from each respiratory period was developed (HTR-AIF). The method was validated using realistic digital phantom simulations and demonstrated on clinical subjects. The GFR estimates using HTR-AIF were compared with estimates obtained by using an AIF derived directly from the view-shared images.
ResultsDigital phantom simulations showed that using the HTR-AIF technique gives more accurate AIF estimates (RMSE=0.0932) compared with the existing estimation method (RMSE=0.2059) that used view-sharing (VS). For simulated GFR>27 mL/min, GFR estimation error was between 32% and 17% using view-shared AIF, whereas estimation error was less than 10% using HTR-AIF. In all clinical subjects, the HTR-AIF method resulted in higher GFR estimations than the view-shared method.
ConclusionThe HTR-AIF method improves the accuracy of both the AIF and GFR estimates derived from the respiratory-gated acquisitions, and makes GFR estimation feasible in free-breathing pediatric subjects. Magn Reson Med 75:1301-1311, 2016.

• 出版日期2016-3