Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs

作者：Singh Erinprit K; Nazarova Lidia A; Lapera Stephanie A; Alexander Leslie D; McAlpine Shelli R^*

来源：Tetrahedron Letters, 2010, 51(33): 4357-4360.

DOI：10.1016/j.tetlet.2010.06.050

Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described HDAC inhibitory activity of these compounds against HeLa cell lysate is evaluated The biological data demonstrate that incorporation of a triazole unit improves the HDAC inhibitory activity Published by Elsevier Ltd

• 出版日期2010-8-18