DIFFERENCES IN VITAMIN D-3 DOSING REGIMENS IN A GERIATRIC COMMUNITY-DWELLING POPULATION

作者：Lagari Violet S^*; Gomez Marin Orlando; Levis Silvina

来源：Endocrine Practice, 2012, 18(6): 847-854.

DOI：10.4158/EP12031.OR

Objective: The adequate dose of vitamin D supplementation for community-dwelling elderly people has not been thoroughly investigated. This study aims to determine the efficacy of a low-dose and a higher dose of vitamin D-3 in maintaining 25-hydroxyvitamin D [25(OH)D] levels at or above 30 ng/mL. %26lt;br%26gt;Methods: This was a single site, double-blind, randomized exploratory clinical trial that enrolled adults 65 years of age and older. Within strata of baseline 25(OH) D levels (%26lt;30 versus %26gt;= 30 ng/mL) subjects were randomized in a 1:2 ratio to receive either 400 or 2,000 IU vitamin D-3 daily for 6 months. The main outcome measures were changes in serum 25(OH)D levels according to baseline 25(OH)D levels and dose of vitamin D-3. %26lt;br%26gt;Results: At baseline, 41 of 105 participants (39%) had low 25(OH)D levels (%26lt;30 ng/mL). After 6 months of vitamin D-3 supplementation, 21 of 32 participants (66%) receiving 400 IU and 14 of 59 participants (24%) receiving 2,000 IU of vitamin D-3 still had low 25(OH)D levels. The largest increases in serum 25(OH)D levels were observed in subjects with baseline levels %26lt;30 ng/mL who received 2,000 IU of vitamin D daily. %26lt;br%26gt;Conclusion: Regardless of baseline 25(OH)D level, in persons 65 years of age and older, 6-month vitamin D-3 supplementation with 400 IU daily resulted in low 25(OH) D in most individuals, while 2,000 IU daily maintained 25(OH)D levels within an acceptable range in most people on this regimen. (Endocr Pract. 2012;18:847-854)

• 出版日期2012-12