A metabolic-transcriptional network links sleep and cellular energetics in the brain

作者：Wisor Jonathan P^*

来源：Pflugers Archiv-European Journal of Physiology, 2012, 463(1): 15-22.

DOI：10.1007/s00424-011-1030-6

• Nicotinamide adenine dinucleotide
• Adenosine triphosphate
• Slow wave activity
• Sleep
• Circadian
• Adenosine monophosphate-activated protein kinase
• Glycogen
• Sirtuin
• Poly(ADP)ribosyl polymerase
• Peroxisome proliferator-activated receptor

This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.

• 出版日期2012-1