Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: Evidence of a weak association in Finns

作者：Pointon Jennifer J^*; Chapman Kay; Harvey David; Sims Anne Marie; Bradbury Linda; Laiho Kari; Kauppi Markku; Kaarela Kalevi; Tuomilehto Jaakko; Brown Matthew A; Wordsworth B Paul

来源：Journal of Rheumatology, 2008, 35(8): 1609-1612.

• ankylosing spondylitis
• genetic studies
• immune system

Objective. To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).
Methods. A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.
Results. In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.
Conclusion. CD14 and TLR4 showed an association with AS in the Firms only.

• 出版日期2008-8