A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A beta, and Frank Neuronal Loss

作者：Cohen Robert M; Rezai Zadeh Kavon; Weitz Tara M; Rentsendorj Altan; Gate David; Spivak Inna; Bholat Yasmin; Vasilevko Vitaly; Glabe Charles G; Breunig Joshua J; Rakic Pasko; Davtyan Hayk; Agadjanyan Michael G; Kepe Vladimir; Barrio Jorge R; Bannykh Serguei; Szekely Christine A; Pechnick Robert N; Town Terrence^*

来源：Journal of Neuroscience, 2013, 33(15): 6245-6256.

DOI：10.1523/JNEUROSCI.3672-12.2013

Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001). The "amyloid cascade hypothesis" posits that cerebral amyloid sets neurotoxic events into motion that precipitate Alzheimer dementia (Hardy and Allsop, 1991). Yet, faithful recapitulation of all AD features in widely used transgenic (Tg) mice engineered to overproduce A beta peptides has been elusive. We have developed a Tg rat model (line TgF344-AD) expressing mutant human amyloid precursor protein (APP(sw)) and presenilin 1 (PS1 Delta E9) genes, each independent causes of early-onset familial AD. TgF344-AD rats manifest age-dependent cerebral amyloidosis that precedes tauopathy, gliosis, apoptotic loss of neurons in the cerebral cortex and hippocampus, and cognitive disturbance. These results demonstrate progressive neurodegeneration of the Alzheimer type in these animals. The TgF344-AD rat fills a critical need for a next-generation animal model to enable basic and translational AD research.

• 出版日期2013-4-10