Antibacterial endiandric acid, derivatives from Beilschmiedia anacardioides

作者：Chouna Jean Rodolphe; Nkeng Efouet Pepin Alango^*; Lenta Bruno Ndjakou; Devkota Krishna Prasad; Neumann Beate; Stammler Hans Georg; Kimbu Samuel Fon; Sewald Norbert

来源：Phytochemistry, 2009, 70(5): 684-688.

DOI：10.1016/j.phytochem.2009.02.012

• Beilschmeidia anacardioides
• Lauraceae
• Beilschmiedic acids A, B and C
• X-ray analysis
• Antibacterial

Three endiandric acid derivatives, beilschmiedic acids A, B and C were isolated from the stem bark of Beilschmiedia anacardioides together with the known beta-sitosterol. Their structures were established by means of modern spectroscopic techniques. The relative configuration of compound 1 was determined by single crystal X-ray analysis. The antibacterial activities of compounds A,B,C were evaluated in vitro against five strains of microbes. Compound C showed strong activity against Bacillus subtilis, Micrococcus luteus and Streptococcus faecalis (MICs below 23 mu M). This Compound was more active than the reference antibiotic ampicillin against B. subtilis and M. luteus.

• 出版日期2009-3