科研之友
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摘要
PEG-400 was found to be a green and recyclable reaction medium for asymmetric hydrogenation of aromatic ketones catalyzed by achiral monophosphine TPPTS (P(m-C(6)H(4)SO(3)Na)(3)), stabilized ruthenium modified by (1S,2S)-DPENDS (DPENDS: disodium salt of sulfonated (1S,25)-1,2-diphenyl-1,2-ethylene-diamine). A 84.9% ee was obtained for acetophenone under the optimized conditions. The resulting products can be easily separated from the catalyst by extraction with n-hexane. The catalyst immobilized on PEG-400 not only exhibits excellent activity and enantioselectivity but also can be recycled and reused several times without loss of activity and enantioselectivity.
