Limited knowledge and use of HIV post- and pre-exposure prophylaxis among gay and bisexual men

作者：Liu Albert Y^*; Kittredge Pravina V; Vittinghoff Eric; Raymond H Fisher; Ahrens Katherine; Matheson Tim; Hecht Jennifer; Klausner Jeffrey D; Buchbinder Susan P

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2008, 47(2): 241-247.

DOI：10.1097/qai.0b013e31815e4041

• postexposure prophylaxis
• pre-exposure prophylaxis
• prevalence

Background: Post-exposure prophylaxis (PEP) is currently recommended after certain high-risk exposures, and pre-exposure prophylaxis (PrEP) is undergoing evaluation in clinical trials. Media reports have suggested substantial levels of community PrEP use despite its unproven effectiveness.
Methods: We conducted a cross-sectional survey of 1819 HIV- uninfected gay/bisexual men in California to assess PEP and PrEP awareness and use.
Results: Overall, 47% reported PEP awareness and 4% ever used PEP. Men who were older than 25 years of age (odds ratio [OR] = 2.2, 95% confidence interval [CI]: 1.5 to 3.1), were white (OR = 2.2, 95% CI: 1.6 to 3.0), had an annual income >$ 100,000 (OR = 2.0, 95% CI: 1.2 to 3.4), self-identified as gay/homosexual (OR = 2.4, 95% CI: 1.4 to 4.3), and had unprotected anal sex (OR 1.8, 95% CI: 1.3 to 2.3) or sex under the influence of a drug (OR 2.0, 95% CI: 1.5 to 2.7) were more likely to be aware of PEP, whereas speed users (OR = 0.6, 95% CI: 0.4 to 0.9) were less likely to be aware of PEP. Only 16% reported PrEP awareness, and < 1 % ever used PrEP. Unprotected anal sex (OR = 1.6, 95% CI: 1.1 to 2.3) and sex under the influence of a drug (OR = 1.5, 95% CI: 1.0 to 2.2) were associated with PrEP awareness.
Conclusions: PEP awareness and use were modest and PrEP use was rare among gay/bisexual men in California. Although PrEP is not currently recommended, community education on the availability of PEP is suggested.

• 出版日期2008-2-1