In Vivo Assessment of Bone Ingrowth Potential of Three-Dimensional E-Beam Produced Implant Surfaces and the Effect of Additional Treatment by Acid Etching and Hydroxyapatite Coating

作者：Biemond J Elizabeth^*; Hannink Gerjon; Jurrius Annemarijn M G; Verdonschot Nico; Buma Pieter

来源：Journal of Biomaterials Applications, 2012, 26(7): 861-875.

DOI：10.1177/0885328210391495

• bone ingrowth
• E-beam
• hydroxyapatite
• acid etching
• surface characterization
• in vivo

The bone ingrowth potential of three-dimensional E-beam-produced implant surfaces was examined by histology and compared to a porous plasma-sprayed control. The effects of acid etching and a hydroxyapatite (HA) coating were also evaluated by histology. Specimens were implanted in the distal femur of 10 goats. Histological analysis of bone ingrowth was performed 6 weeks after implantation. The E-beam-produced surfaces showed significantly better bone ingrowth compared to the plasma-sprayed control. Additional treatment of the E-beam surface structures with a HA coating, further improved bone ingrowth potential of these structures significantly. Acid etching of the E-beam structures did not influence bone ingrowth significantly. In conclusion, the HA-coated, E-beam-produced structures are promising potential implant surfaces.

• 出版日期2012-3