MicroRNA-1 in Cardiac Diseases and Cancers

作者:Li, Jianzhe; Dong, Xiaomin; Wang, Zhongping; Wu, Jianhua*
来源:Korean Journal of Physiology and Pharmacology, 2014, 18(5): 359-363.
DOI:10.4196/kjpp.2014.18.5.359

摘要

MicroRNAs (miRs) are endogenous approximate to 22-nt non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. MiR-1 is one of the muscle-specific miRs, aberrant expression of miR-1 plays important roles in many physiological and pathological processes. In this review, we focus on the recent studies about miR-1 in cardiac diseases and cancers. The findings indicate that miR-1 may be a novel, important biomarker, and a potential therapeutic target in cardiac diseases and cancers.