Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis

作者：Bruneau Benoit G^*

来源：Canadian Journal of Physiology and Pharmacology, 2011, 89(8): 533-537.

DOI：10.1139/Y11-051

• atrial natriuretic factor
• heart
• embryology
• gene expression
• transcription factors
• congenital heart disease
• patterning

The developing heart forms during the early stages of embryogenesis, and misregulated heart development results in congenital heart defects (CHDs). To understand the molecular basis of CHDs, a deep understanding of the morphological and genetic basis of heart development is necessary. Atrial Natriuretic Factor (ANF) is an important and extremely sensitive marker for specific regions of the developing heart, as well as for disturbances in the patterning of the heart. This review summarizes the dynamic expression of ANF in the developing heart and its usefulness in understanding the early molecular defects underlying CHDs.

• 出版日期2011-8