Antiprotozoal activity of Betulinic acid derivatives

作者：Dominguez Carmona D B; Escalante Erosa F; Garcia Sosa K; Ruiz Pinell G; Gutierrez Yapu D; Chan Bacab M J; Gimenez Turba A; Pena Rodriguez L M^*

来源：Phytomedicine, 2010, 17(5): 379-382.

DOI：10.1016/j.phymed.2009.08.002

• Pentalinon andriexii
• Betulinic acid
• Leishmanicidal
• Trypanocidal
• Antiplasmodial

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

• 出版日期2010-4