Activation of telomerase by HPVs

作者：Katzenellenbogen Rachel A^*

来源：Virus Research, 2017, 231: 50-55.

DOI：10.1016/j.virusres.2016.11.003

• HPV E6
• HPV E7
• hTERT
• Telomerase

Telomerase extends the ends of linear chromosomes, and its expression leads to cellular immortalization. In HPV-associated cancers, telomerase is universally detected, and this occurs by activation of the catalytic subunit of telomerase, hTERT. The expression of hTERT is affected by both high-risk HPV E6 and E7. Seminal studies over the last two decades have identified the transcriptional, epigenetic, and post-transcriptional roles high-risk E6 and E7 have in telomerase regulation. This review will summarize these findings and highlight the importance of telomerase activation as an oncogenic pathway in HPV-associated cancer development and progression.

• 出版日期2017-3-2