A longitudinal study,on patients with diabetes and symptoms of gastroparesis - associations with impaired quality of life and increased depressive and anxiety symptoms

作者：Teigland Tonje; Iversen Marjolein M; Sangnes Dag A; Dimcevski Georg; Softeland Eirik^*

来源：Journal of Diabetes and Its Complications, 2018, 32(1): 89-94.

DOI：10.1016/j.jdiacomp.2017.10.010

• Diabetes
• Gastroparesis
• Quality of life
• Autonomic neuropathy
• Anxiety
• Depression

Aims: To examine patient reported outcomes (PRO) in patients previously assessed for diabetic gastroparesis, and to investigate how symptoms of gastroparesis evolve over time. In addition, to further evaluate outcomes in those with versus without diabetic gastroparesis at baseline.
Methods: Thirty-four patients with diabetes and gastrointestinal (GI) symptoms, diagnosed with or without diabetic gastroparesis in 2011-2013, were included in this follow-up study. PRO were measured with the Patient assessment of upper gastrointestinal symptom severity index (PAGI-SYM), 36-Item Short Form Survey (SF 36), Patient assessment of upper gastrointestinal disorders-quality of life (PAGI-QOL) and Hospital Anxiety and Depression Scale (HADS). Demographic factors and clinical variables were also recorded.
Results: Participants diagnosed with gastroparesis had improved glycemic control (p = 0.04) and less GI symptoms (p = 0.001), after a follow-up time of 32 years (mean). Both groups reported severely impaired quality of life (QoL). In total 47% reported symptoms of anxiety, 38% symptoms of depression (scores ?: 8). GI symptom severity or other PRO could not differentiate between the two groups.
Conclusions: Patients diagnosed with diabetic gastroparesis, as well as those with gastroparesis symptoms - but normal gastric emptying, suffer from severely impaired QoL and a high burden of anxiety and depressive symptoms.

• 出版日期2018-1