Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors

作者：Dharmaraja Allimuthu T; Alvala Mallika; Sriram Dharmarajan; Yogeeswari Perumal; Chakrapani Harinath^*

来源：Chemical communications, 2012, 48(83): 10325-10327.

DOI：10.1039/c2cc35343a

Here, we report 5-hydroxy-1,2,3,4,4a,9a-hexahydro-1,4-ethano9,10-anthraquinone (13), a small molecule generating reactive oxygen species (ROS) in pH 7.4 buffer under ambient aerobic conditions that has selective and potent Mycobacterium tuberculosis growth inhibitory activity.

• 出版日期2012