A Pro-metastatic tRNA Pathway

作者:Kuscu Canan; Dutta Anindya
来源:Cell, 2016, 165(6): 1314-1315.
DOI:10.1016/j.cell.2016.05.066

摘要

tRNAs are best known as basic modules for global regulation of protein synthesis. Goodarzi et al. now show that two tRNAs upregulated in metastatic breast cancer cells enhance stability and translation of transcripts enriched with these codons, leading to specific increase in production of prometastatic proteins.

  • 出版日期2016-6-2