Association of Angiotensin-Converting Enzyme I/D and eNOS G894T Gene Polymorphisms with Erectile Dysfunction

作者：Cam F Sirri^*; Gumus Bilali H; Var Ahmet; Berdeli Afig

来源：Turkiye Klinikleri Tip Bilimleri Dergisi, 2011, 31(2): 432-437.

DOI：10.5336/medsci.2009-16635

• Erectile dysfunction
• polymorphism
• angiotensin-converting enzyme

Objective: Recent studies suggest that angiotensin II and nitric oxide (NO) may modulate penile smooth muscle tone and contractility. Because genotypes of the angiotensin converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with disorders in the vascular system, in this study, we investigated an association between the ACE I/D and eNOS G894T gene polymorphisms and erectile dysED). Material and Methods: A total of 44 patients and 45 control subjects were included in the study. Diagnosis of erectile dys< 26) was provided by International Index of Erectile IIEF). The ACE I/D ye eNOS G894T gene polymorphisms were genotyped using PCR and RFLP. Results: No significant case-control difference was observed for the ACE I/D and eNOS G894T gene polymorphisms either by genotype or allele frequencies [(ACE I/D-X-2=0.930 p=0.628) and eNOS 894 G/T-X-2=2.114 p=0.348)]. In addition, there was no significant difference between ACE I/D (X-2=3.174 p=0.787) and eNOS G894T (X-2=4.320 p=0.633) and IIEF scores among the patient group. Conclusion: In this study, no association was found between ACE LID and eNOS G894T gene polymorphisms and erectile dysfunction in the Turkish population studied.

• 出版日期2011-4